Research
New Findings on the Use of Dolutegravir in Pregnancy
A recent comparative study in the New England Journal of Medicine reports on the benefits of Dolutegravir in pregnancy compared to other HIV regimens currently used in the United States.
Patel K, Huo Y, Jao J, et al. Dolutegravir in pregnancy as compared with current HIV regimens in the…
Mental Health in Women Living with HIV
In this review, the authors explore the unique mental health issues faced by women living with HIV and examine the feasibility and outcomes of mental health interventions that have been tested in this population.
Citation: Waldron EM, Burnett-Zeigler I, Wee V, Ng YW, Koenig LJ,…
Third Trimester Repeat HIV Testing: It's Time We Make it Universal
This clinical opinion piece is the Illinois Perinatal HIV Hotline team's call to action for universal repeat third trimester HIV testing as a key strategy toward perinatal HIV elimination.
Citation: Cassimatis IR, Ayala LD, Miller ES, Garcia PM, Jao J, Yee LM. Third trimester repeat…
Housing Instability and Virologic Control Among Pregnant Individuals with HIV
The authors, including many of the clinicians on the Illinois Perinatal HIV Hotline, examine the association between housing instability and HIV outcomes in pregnant individuals living with HIV.
Citation: Cassimatis IR, Miller ES, Benes L, Levesque J, Yee LM. Housing instability is…
Safety of Early Nevirapine Therapy for Neonates at High Risk for Perinatal HIV Infection
This study examined the pharmacokinetics and safety of nevirapine for use in the early neonatal period. The authors found that nevirapine at the dose studied was confirmed to be safe, and that the data support nevirapine as a component of presumptive HIV treatment in high-risk neonates.…
Communication About Partner HIV Testing in the U.S.
This qualitative study in a high HIV prevalence U.S. city explored communication about HIV testing among pregnant HIV-negative women and their male partners. The authors suggest future research is needed to assess specific barriers to male partner HIV testing as an approach to preventing…
Social Vulnerability among Foreign-Born Pregnant Women and Virologic Control of HIV
This study assessed the relationship between social vulnerability among foreign-born pregnant women living with HIV and maternal viremia during pregnancy. The authors found virologic control during pregnancy to be worse among socially-vulnerable women and recommend closer follow-up and…
Pregnancy Intention and Viral Suppression Among Pregnant Women with HIV
This study examines pregnancy intention and its relationship to achieving viral suppression by delivery. The authors found that women with an unintended pregnancy were less likely to be on antiretroviral therapy prior to initiating prenatal care and were less likely to be virally suppressed…
SMFM Releases Updated Checklists for Management of HIV in Pregnancy
The Society for Maternal-Fetal Medicine has published updated and expanded checklists to help ensure that all relevant elements are considered for every person with HIV during prepregnancy, antepartum, intrapartum, and postpartum periods. The checklists are intended to be used as tools to…
Data Support Nevirapine for Presumptive Treatment in High Risk Neonates
Recent findings from the IMPAACT P1115 study confirm the safety and therapeutic drug concentrations of a nevirapine-based antiretroviral regimen in the early neonatal period. The study's aim was to establish dosing of nevirapine for very early treatment of HIV-exposed neonates at high risk of…
Updated AAP Guidance for Infants Exposed to HIV
Updated in October 2020, this clinical report from the American Academcy of Pediatrics provides guidance on the evaluation and management of infants born to women living with HIV.
Citation: Chadwick EG. AAP Committee on Pediatric AIDS. Evaluation and management of the infant exposed to…
COVID-19 Among People Living with HIV
This issue of AIDS includes a special section on the intersection of COVID-19 and people living with HIV.
AIDS October 1, 2020 - Volume 34 - Issue 12
HIV PrEP for Conception Among Serodiscordant Couples
This article describes a prospective cohort study to assess the feasibility, perceptions, and adherence associated with periconceptional PrEP use among females without HIV and their male partners living with HIV across four academic medical centers in the United States.
Citation: Leech AA,…
Attitudes Towards Male Partner HIV Testing
This study, by members of the Illinois Perinatal HIV Hotline medical leadership team, explores the attitudes of pregnant women and their partners toward partner HIV testing.
Citation: Yee LM, Leziak K, Jackson J, Miller ES. Attitudes towards male partner HIV testing among…
Safety of In-Utero ARV Exposure
A recent study of neurological outcomes in children who are HIV-exposed but uninfected found some increased risk of neurologic abnormalities. These risks were associated with exposure to efavirenz and didanosine. Dolutegravir expsoure showed some suggestive associations that the authors suggest…
Epidemiology of Perinatal HIV Transmission in the U.S.
This article examines the most recent epidemiology of perinatal HIV transmission in the United States in the era of elimination. It looks at the perinatal HIV prevention cascade, annual births to women with HIV, the population of women living with HIV, and their geographical distribution…
Reproductive Years of Women with Perinatally Acquired HIV
This article, written by members of the IL Perinatal HIV Hotline team, reviews existing evidence regarding the gynecologic and obstetric issues unique to reproductive age women with perinatally acquired HIV.
Citation:
Berhie S, Yee L, Jao J. The reproductive years of women with…
Eliminating Perinatal HIV in the United States
In this article, the authors describe progress thus far toward the goal of perinatal HIV elimination in the United States. They describe different approaches to perinatal HIV preventive services in the District of Columbia and five states, including Illinois. They conclude by sharing strategies…
Trends in Neonatal Prophylaxis in US Infants
In this article, the authors describe the use of neonatal prophylaxis over time. They observed overall low rates of combination prophylaxis, including for those infants at higher risk, demonstrating inconsistency with current guidelines in the United States.
Citation:
Williams PL, Huo Y,…
Intimate Partner Violence and HIV Care in Pregnancy
In this article, the authors describe the relationship between intimate partner violence (IPV) and ARV adherence and viral suppression in pregnancy. They conclude that IPV during a pregnancy is associated with decreased ARV adherence and delays in achieving virologic suppression.…
Stigma and the Elimination of Perinatal HIV in the U.S.
In this article, the authors describe the relationship between stigma toward pregnant women with HIV and efforts to eradicate perinatal HIV transmission. They conclude that stigma plays a significant role in the inability of the U.S. to eliminate MTCT of HIV.
Citation:
Arora KS,…
Perinatal HIV Service Coordination
In this article, the authors describe a comprehensive concept of perinatal HIV service coordination. The authors identify six core functions to close the gap in the HIV care continuum for pregnant women and prevent perinatal transmission of HIV in the United States.
Citation: Andrews MM…
Risk of Acquiring HIV Increases During and After Pregnancy
New research suggests a woman’s risk of acquiring HIV through sex with a male partner living with HIV increases during pregnancy and is highest during the postpartum period. Click here to read more about this research presented at the 2018 CROI Conference.
Sustainability of Perinatal Rapid HIV Testing in Illinois
In this article, the authors utilized a retrospective cohort study of women delivered in Illinois hospitals (2012-2015) to assess the sustainability of Illinois' statewide program of HIV rapid testing for pregnant women presenting for delivery with unknown HIV status. They found that…
Missed Perinatal HV Prevention Opportunities in FL
The authors analyzed data pertaining to children born between 2007 and 2014 and perinatally exposed to HIV. Among other findings, perinatal transmission was most strongly associated with maternal HIV diagnosis during labor and delivery or after birth.
Citation:
Trepka MJ,…